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Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B 12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting.” Clinical practice guidelines British Columbia Medical Services Commission (MSC)

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histologically, they appear as distended, weakly-staining cells with large, realtively clear nuclei) and brain edema were described and evaluated semiquantitatively (22)